Our research focuses on the following topics:
- Developing resources to support the analysis of immunoglobulin (IG) genomic information, notably OGRDB and, in collaboration with Gur Yaari's lab (Bar Ilan University), VDJbase.
- Using deep learning to aid the interpretation of adaptive immune repertoire data
- Using molecular dynamics simulations to model antibody/antigen binding and viral entry machinery (notably that of hepatitis C virus)
- Making predictions at the boundary between self and non-self that aid the stratification of patient responses to viral pathogens, therapeutic proteins and tumour antigens.
- Various members of The AIRR (Adaptive Immune Receptor Repertoire) Community (now part of The Antibody Society), notably via participation in the Software Working Group and Germline Database Working Group.
- Dr Michele Mishto (Senior Lecturer in Immunobiology, KCL/Crick)
- Prof Flemming Hansen (Chair of NMR Spectroscopy, UCL)
- Dr Dan Hart (Consultant in Haemostasis, Barts/Queen Mary)
- Dr Joe Grove (MRC-University of Glasgow Centre for Virus Research)
- Dr Shilpa Chokshi (Scientific Manager, Institute of Hepatology)
Joining the Group
Current internship vacancies. We are currently interested in recruiting interns to work on Next Generation Sequencing (NGS) applied to immune system repertoires and related topics. These positions would suit graduates with good programming skills wishing to gain a track record in NGS research. Projects are also available for people with immunological expertise.
General recruitment. We are keen to recruit highly motivated and talented people to work in our group, ranging from undergraduate to post-doctoral level. All interested individuals are encouraged to email Dr Shepherd (firstname.lastname@example.org), but please bear in mind the following points:
Funding. The group has no earmarked funding available unless it is clearly advertised on this page. PhD studentships are available at specific times of the year through the ISMB PhD Programmes. Applications must be made via that website, but feel free to get in touch informally if you wish to discuss possible projects. The same advice applies to internships, for which support is available through the ISMB Summer Internship Programme. For those who are unable to get funding, it is worth noting that Birkbeck specializes in part-time education for people in work, including at PhD level.
Skills. All our work is computational. We welcome applications from from people with good programming skills (in any language) and/or specialist knowledge about the human immune system. We are also happy to consider applications from those with other bioinformatics skills and interests, such as homology modelling.
We would like to thank the following organisations for supporting our research: